Doctors are reporting a side effect known as 'Ozempic feet,' which refers to changes in the appearance and comfort of feet in individuals using GLP-1 medications for weight loss. This condition can manifest as feet that appear bonier, feel painful, or no longer fit properly. Dr. Claire Morrow, an orthopedic clinical specialist, explains that these changes are often due to rapid weight loss rather than the medications themselves. The phenomenon is not listed among the most common side effects of Ozempic or Wegovy, but it can occur when weight loss is significant, leading to loose or sagging skin on the feet.
The popularity of GLP-1 medications has increased since the FDA approved Wegovy for chronic weight management in 2021, with a KFF poll indicating that about 12.5% of U.S. adults reported using such medications. Dr. Morrow cautions that the skin may not adjust quickly enough to rapid weight loss, resulting in a bony appearance, particularly on the tops of the feet.
Dr. Dana Figura, a podiatric specialist, notes that some patients report discomfort, such as feeling like they are walking on pebbles, and experiencing heel pain or shoe-fit issues. As fat pads under the feet thin out, shock absorption decreases, potentially leading to further discomfort. Some patients have reported a decrease in shoe size, which can cause instability and blisters.
Research indicates that 25% to 40% of weight loss during GLP-1 treatment may come from lean mass, which can affect the stability of the feet. Dr. Morrow advises that individuals losing more than 15% to 20% of their body weight in a year may be at increased risk for these changes. To mitigate side effects, doctors recommend maintaining protein intake, engaging in resistance training, and consulting a physician if weight loss is rapid. Adjusting medication doses may also help achieve a more gradual weight loss. Additionally, patients are encouraged to have their feet measured regularly and to use cushioning in their shoes to accommodate changes in foot structure.