Research presented at the ANESTHESIOLOGY 2026 annual meeting suggests that taking melatonin or Ambien before surgery may help reduce pain and opioid use. The study analyzed data from over 1,100 patients across various surgical procedures, finding that melatonin was associated with lower anxiety and inflammation, while Ambien aided those with pre-existing sleep issues. The authors noted that further research is needed to draw definitive clinical recommendations.
Key facts
- Research analyzed 16 studies involving over 1,100 patients from 2000 to 2025.
- Melatonin dosages ranged from 1 mg to 20 mg, taken before surgery.
- Ambien was taken at a consistent dose of 10 mg, either before or leading up to surgery.
- Melatonin use was linked to over a 30% reduction in opioid use in some patients.
- Further research is needed to establish clinical recommendations.
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